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ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors

โœ Scribed by Matthias Scholz; Anna L. Blobaum; Lawrence J. Marnett; Evamarie Hey-Hawkins

Book ID
116318505
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
470 KB
Volume
20
Category
Article
ISSN
0968-0896

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๐Ÿ“œ SIMILAR VOLUMES

From indomethacin to a selective COX-2 i
From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors
โœ W.C. Black; C. Bayly; M. Belley; C.-C. Chan; S. Charleson; D. Denis; J.Y. Gauthi ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 307 KB

A series of potent and highly selective cyclooxygenase-2 inhibitors have been prepared by replacing the benzoyl group of indomethacin with a 4-bromobenzyl group, and by extending the acetic acid side chain. These compounds show anti-inflammatory activity in rats with no evidence of GI toxicity, even