Ornithine decarboxylase and polyamine levels are reduced in CHO cells deficient in cAMP-dependent protein kinase
β Scribed by Max Costa; Maryellen de Mars; Shen Nan Lin
- Book ID
- 115755959
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 446 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0006-291X
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We have previously shown that in Chinese hamster ovary (CHO) cells, a mutant cell line with a defective regulatory subunit (RI) for the CAMP-dependent protein kinase (Abraham et al: Mol. Cell. Biol., 7:3098-3106, 19871, and a transfectant cell line expressing the same mutant kinase, showed increased
## Abstract DNAβdependent protein kinase (DNAβPK), a nuclear serine/threonine kinase, is responsible for the DNA doubleβstrand break repair. Cells lacking or with dysfunctional DNAβPK are often associated with misβrepair, chromosome aberrations, and complex exchanges, all of which are known to cont
## Abstract Ornithine decarboxylase (ODC) inductions by cholera toxin and by the phorbol ester tumor promoter, TPA, were compared in wildβtype Chinese hamster ovary (CHO) cells and in mutant cells having altered cyclic AMPβdependent protein kinase activity. The aim of these studies was to determine