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Origin of the Supernumerary Chromosome in Trisomy 21

✍ Scribed by J.-F. Mattei; M.-G. Mattei; S. Ayme; F. Giraud


Book ID
119838740
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
146 KB
Volume
14
Category
Article
ISSN
0009-9163

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Origin of the extra chromosome in trisom
✍ J. F. Mattei; M. G. Mattei; S. Ayme; F. Giraud πŸ“‚ Article πŸ“… 1979 πŸ› Springer 🌐 English βš– 230 KB

Of 61 families of children with trisomy 21, polymorphism of chromosome 21 elucidating the origin of the extra chromosome was found in 42. Nondisjunction was of paternal origin in 8 cases (19.04%) and the anomaly occurred with equal frequency during the first and second meiotic divisions. Maternal no