Origin of the extra chromosome in trisomy 18
β Scribed by Tatsuro Kondoh; Hidefumi Tonoki; Tadashi Matsumoto; Masato Tsukahara; Norio Niikawa
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 213 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0340-6717
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Of 61 families of children with trisomy 21, polymorphism of chromosome 21 elucidating the origin of the extra chromosome was found in 42. Nondisjunction was of paternal origin in 8 cases (19.04%) and the anomaly occurred with equal frequency during the first and second meiotic divisions. Maternal no
Chromosome 21 fluorescent heteromorphisms were studied in 42 patients with Down's syndrome, their parents and their siblings. Included in this number are two instances of an aunt and niece affected with trisomy 21, and one of affected siblings. One case has a de novo 21/21 translocation. Blood group