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ORIGIN OF RETINOBLASTOMA

✍ Scribed by Howard, RufusO.


Book ID
123489945
Publisher
The Lancet
Year
1982
Tongue
English
Weight
321 KB
Volume
320
Category
Article
ISSN
0140-6736

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The retinoblastoma susceptibility (RB1) gene contains an unmethylated CpG-rich island at its 5' end. Using methylation-sensitive restriction enzymes, we have investigated the methylation status of this island in 21 sporadic unilateral retinoblastomas and 30 hereditary retinoblastomas. Three sporadic