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Parental origin of mutations of the retinoblastoma gene

✍ Scribed by Dryja, Thaddeus P.; Mukai, Shizuo; Petersen, Robert; Rapaport, Joyce M.; Walton, David; Yandell, David W.


Book ID
109759182
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
389 KB
Volume
339
Category
Article
ISSN
0028-0836

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The retinoblastoma susceptibility (RB1) gene contains an unmethylated CpG-rich island at its 5' end. Using methylation-sensitive restriction enzymes, we have investigated the methylation status of this island in 21 sporadic unilateral retinoblastomas and 30 hereditary retinoblastomas. Three sporadic