✦ LIBER ✦

Origin of acrocentric trisomies in spontaneous abortuses

✍ Scribed by Norio Niikawa; Elisabeth Merotto; Tadashi Kajii

Publisher: Springer
Year: 1977
Tongue: English
Weight: 289 KB
Volume: 40
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00280832

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✦ Synopsis

A total of 33 spontaneous abortuses with various acrocentric trisomies were studied for the origin of the extra chromosomes using Q- and R-band polymorphisms as markers. Eleven trisomic abortuses were informative: nine trisomic abortuses (one with trisomy 13, three with trisomy 21, and five with trisomy 22 including one with a 46,XX/47,XX,+22 mosaicism) originated at maternal first meiosis; a 21-trisomic abortus resulted from an error at maternal second meiosis (or first mitosis); and a 13-trisomic abortus was of maternal first or second meiotic origin. The abortus with mosaic trisomy 22 started as a 22-trisomic zygote resulting from an error at maternal first meiosis, followed by a mitotic (in vivo or in vitro) loss of the paternally derived chromosome 22.

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