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The origin of trisomy 22: Evidence for acrocentric chromosome-specific patterns of nondisjunction

✍ Scribed by Heather E. Hall; Urvashi Surti; Lori Hoffner; Sofia Shirley; Eleanor Feingold; Terry Hassold

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 131 KB
Volume: 143A
Category: Article
ISSN: 1552-4825
DOI: 10.1002/ajmg.a.31918

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✦ Synopsis

Abstract

Trisomy 22 is one of the most common trisomies in clinically recognized pregnancies, yet relatively little is known about the origin of nondisjunction for chromosome 22. Accordingly, we initiated studies to investigate the origin of the extra chromosome in 130 trisomy 22 cases. Our results indicate that the majority of trisomy 22 errors (>96%) arise during oogenesis with most of these errors (∼90%) occurring during the first meiotic division. As with other trisomies, failure to recombine contributed to nondisjunction of chromosome 22. Taken together with data available for other trisomies, our results suggest patterns of nondisjunction that are shared among the acrocentric, but not all nonacrocentric, chromosomes. © 2007 Wiley‐Liss, Inc.

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