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Orientation and Conformation of a Lipase at an Interface Studied by Molecular Dynamics Simulations

✍ Scribed by Jensen, Morten Ø.; Jensen, Torben R.; Kjaer, Kristian; Bjørnholm, Thomas; Mouritsen, Ole G.; Peters, Günther H.


Book ID
118514664
Publisher
Biophysical Society
Year
2002
Tongue
English
Weight
803 KB
Volume
83
Category
Article
ISSN
0006-3495

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Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully ␣-helical one, and one where 87-90 form a typ