Recent reports indicate that antibodies associated with heparin-induced thrombocytopenia and thrombosis (HITP) are specific for complexes formed between heparin and the heparin-binding, platelet alpha granule protein, platelet factor 4 (PF4). As with other disorders mediated by immune complexes (IC)
Orgaran during rotational atherectomy in the setting of heparin-induced thrombocytopenia
β Scribed by Hale, L. Paulette ;Smith, Karen ;Braden, Gregory A. ;Owen, John
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 143 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0098-6569
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β¦ Synopsis
Heparin is considered necessary during percutaneous coronary interventions; however, heparin is contraindicated in patients with heparin-induced thrombocytopenia and/or heparin antibodies. We describe the successful use of the heparinoid Orgaran (danaparoid sodium) in addition to abciximab (ReoPro) in a patient with heparin antibodies who required rotational atherectomy.
π SIMILAR VOLUMES
Heparin-induced thrombocytopenia and thrombosis syndrome (HITTS) is a severe complication of heparin caused by an antibody response to the heparin-platelet factor 4 complex which results in severe thrombosis. Heparin rechallenge in HllTS patients carries a high risk of inducing thrombosis. Antithrom
## Abstract Heparinβinduced thrombocytopenia (HIT), which is characterized by thrombocytopenia and potentially serious thromboses, may develop in patients exposed to heparin anticoagulation. HIT is caused by antibodies to the heparin/platelet factor 4 (PF4) complex. Management of HIT involves disco