Organosilane-mediated free radical cyclization reactions employing carbonyl traps

✍ Scribed by Robert A. Batey; D. Bruce MacKay

• Book ID: 104259911
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 253 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01585-8

✦ Synopsis

Free-radical cyclization of halocarbonyl compounds can be achieved using the organosilane reagents phenylsilane and tristrimethylsilylsilane. Both 6-exotrig and 5-exo-trig cyclizations can be accomplished using aldehydes or ketones as radical traps.