Organometallic complexes with biological molecues, part 3. in vivo cytotoxicity of diorganotin (IV) chloro and triorganotin (IV) chloro derivatives of penicillin g on chromosomes of aphanius fasciatus (pisces, cyprinodontiformes)

✍ Scribed by R. Vitturi; C. Mansueto; A. Gianguzza; F. Maggio; A. Pellerito; L. Pellerito

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 504 KB
• Volume: 8
• Category: Article
• ISSN: 0268-2605
• DOI: 10.1002/aoc.590080603

✦ Synopsis

In order to obtain a continuous source of mitotic metaphases, gill tissue of Aphanius fasciutus (Pisces, Cyprinodontiformes) has been successfully employed. Results gathered after exposure of fish to R,SnClpenG, R,SnClpenCNa, to the parents R2SnC12, R&3nCI and to penGNa (penGNa= penicillinGNa; R = methyl, butyl and phenyl) suggest that both the parent organotin(IV'rh1oride and organotin(1V)chloropenG derivatives are toxic while penGNa exerts no significant toxic activity. Essentially, all of the chromosome abnormalities are classifiable as irregularly staining of chromosomes, breakages, side-arm bridges or pseudwhiasmata.