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Organocerium reagents. Nucleophilic addition to easily enolizable ketones

✍ Scribed by Tsuneo Imamoto; Yasushi Sugiura; Nobuyuki Takiyama

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
229 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis

Organocerium reagents, prepared from organolithiums and anhydrous cerium (III) chloride, react cleanly with easily enolizable ketones to afford the addition products in good to excellent yields. The nucleophilic addition of Grignard or lithium reagents to carbonyl compounds is undoubtedly one of the most versatile reactions in synthetic organic chemistry.

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