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Organocatalytic synthesis of α-hydroxy and α-aminophosphonates

✍ Scribed by Seyed Mohammad Vahdat; Robabeh Baharfar; Mahmood Tajbakhsh; Akbar Heydari; Seyed Meysam Baghbanian; Samad Khaksar

Book ID
108285176
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
165 KB
Volume
49
Category
Article
ISSN
0040-4039

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📜 SIMILAR VOLUMES

Enantioselective synthesis of β-hydroxy-
Enantioselective synthesis of β-hydroxy-α-aminophosphonic acid precursors
✍ Antonio Togni; Stephen D. Pastor 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 154 KB

The gold(I) catalyzed aldol reaction of diethyl a-isocyanomethylphosphonate with benzaldeyde gave the oxazoline 3, a P-hydroxy-a-aminophosphonic acid precursor, with high enantioand diastereoselectivity (98 % tram, 85 % ee) by employing a chiral ferrocenylamine ligand. The use of 31P NMR spectroscop