Organocatalytic Highly Enantioselective Conjugate Addition of Aldehydes to Alkylidine Malonates
✍ Scribed by Gui-Ling Zhao; Jan Vesely; Junliang Sun; Kirsten E. Christensen; Charlotte Bonneau; Armando Córdova
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 267 KB
- Volume
- 350
- Category
- Article
- ISSN
- 1615-4150
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📜 SIMILAR VOLUMES
Even though the first reports of enantioselective organocatalysis by Wiechert et al. and Hajos and Parrish appeared almost three decades ago, [1] the field of asymmetric catalysis has been dominated by metal catalysis. It is only recently that asymmetric organocatalysis has received renewed attentio
## Abstract The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.
Organocatalysis [1] has expanded widely within the last few years, since the rediscovery of the proline-catalyzed aldol reaction. [2] Since then, several different methods, such as fluorination, [3] chlorination, [4] bromination, [5] sulfenylation, [6] amination, [7] and Mannich reactions, [8] have