Organocatalytic Enantioselective Sulfenylation of β-Keto Phosphonates: A Convenient Approach to Construct Hetero- Quaternary Stereocenters

✍ Scribed by Aijun Lin; Ling Fang; Xi Zhu; Chengjian Zhu; Yixiang Cheng

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 202 KB
• Volume: 353
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.201000679

✦ Synopsis

Abstract

The highly effective and enantioselective sulfenylation of β‐keto phosphonates catalyzed by α,α‐diaryl‐L‐prolinols has been developed. The optically active α‐sulfenylated β‐keto phosphonates could be obtained under mild reaction conditions in good yields (up to 92%) and with excellent enantioselectivities (up to 92% ee).