Organocatalytic enantioselective conjugate addition–cyclization domino reactions of o-N-protected aminophenyl α,β-unsaturated aldehydes
✍ Scribed by Heo, Seungpyeong; Kim, Shinae; Kim, Sung-Gon
- Book ID
- 120619344
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 710 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Organocatalysis [1] has expanded widely within the last few years, since the rediscovery of the proline-catalyzed aldol reaction. [2] Since then, several different methods, such as fluorination, [3] chlorination, [4] bromination, [5] sulfenylation, [6] amination, [7] and Mannich reactions, [8] have
## Abstract The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.