β Scribed by Amal Ting; Scott E. Schaus
No coin nor oath required. For personal study only.
The direct, asymmetric Mannich reaction catalyzed by small organic molecules offers a facile route to optically active Ξ±β or Ξ²βamino acid derivatives and 1,2β and Ξ³βamino alcohols. Oneβpot reactions of unmodified carbonyl donors with preformed or in situ generated imines can be stereochemically controlled with Organic catalysts such as proline, chiral pyrrolidines, chiral BrΓΈnsted acids, and Cinchona alkaloids. The generated Mannich adducts can be further functionalized towards a variety of bioactive molecules. In this Microreview, recent contributions are discussed to present the methodology and synthetic advantages achieved so far in the asymmetric Mannich reaction. (Β© WileyβVCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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The applications of arene-catalyzed lithiation reactions and esters. This arene-catalyzed lithiation has also been used in the preparation of polylithiated intermediates. Sub-during recent years are reviewed. This methodology has been used to obtain functionalized organolithium compounds stoichiomet