The applications of arene-catalyzed lithiation reactions and esters. This arene-catalyzed lithiation has also been used in the preparation of polylithiated intermediates. Sub-during recent years are reviewed. This methodology has been used to obtain functionalized organolithium compounds stoichiometric amounts of the arene may be supported on a polymeric material, its catalytic activity being as efficient as from halogenated as well as nonhalogenated materials, such as heterocycles, sulfones, triflates, ethers, thioethers, amides, in the solution version.
perimental and theoretical work makes lithium chemistry a
Introduction
branch of chemistry in itself. [1] The importance of lithium derivatives continues to grow
The replacement of hydrogen by lithium in an organic due to the versatility of these reagents in the synthesis of compound is a versatile method for preparing organolinovel inorganic, organometallic, organic, and bioorganic thium compounds. The general principle involved in this compounds. This widespread use, together with the peculiar reaction is, on the one hand, the use of a relatively strongly properties of lithium due to its small size, has led to a conacidic hydrocarbon (pK a Յ 33) or the presence in the α-or siderable interest in the generation, structures, and reactivβ-position of a heteroatom that increases the kinetic and/or ity of organolithium compounds. The great volume of exthermodynamic acidity of a particular hydrogen atom, and, on the other hand, the use of a strong base such as an organolithium compound or a lithium amide. However, this [a] Departamento de Quı ´mica Orga ´nica, Universidad de Alicante, method is not available for a wide range of organic starting