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Organocatalytic asymmetric aldol reaction in the presence of water

โœ Scribed by Gryko, Dorota; Saletra, Wojciech J.


Book ID
115470654
Publisher
Royal Society of Chemistry
Year
2007
Tongue
English
Weight
132 KB
Volume
5
Category
Article
ISSN
1477-0520

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Organocatalytic asymmetric syn-selective
โœ Yong-Chua Teo; Guan-Leong Chua; Chin-Yee Ong; Chai-Yun Poh ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 543 KB

A practical and convenient organocatalytic strategy is developed to provide a direct route to syn-selective aldol products in the presence of water. The siloxy serine organocatalyst mediates the direct aldol reaction of TBSO-protected hydroxyacetone with a variety of aldehydes to provide the aldol p