Organocatalytic and direct asymmetric vinylogous Michael addition of 3-cyano-4-methylcoumarins to α,β-unsaturated ketones

✍ Scribed by Xiong Huang; Yi-Hang Wen; Fei-Ting Zhou; Ce Chen; Dong-Cheng Xu; Jian-Wu Xie

• Book ID: 104098463
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 498 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.10.055

✦ Synopsis

The first highly regio-, chemo-, and enantio-selective direct vinylogous Michael addition of 3-cyano-4methylcoumarin derivatives to a,b-unsaturated ketones is described, employing readily available 9amino-9-deoxy-epiquinine as the iminium organocatalyst.