Organocatalytic and direct asymmetric vi
✍
Xiong Huang; Yi-Hang Wen; Fei-Ting Zhou; Ce Chen; Dong-Cheng Xu; Jian-Wu Xie
📂
Article
📅
2010
🏛
Elsevier Science
🌐
French
⚖ 498 KB
The first highly regio-, chemo-, and enantio-selective direct vinylogous Michael addition of 3-cyano-4methylcoumarin derivatives to a,b-unsaturated ketones is described, employing readily available 9amino-9-deoxy-epiquinine as the iminium organocatalyst.