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Organ culture of psoriatic skin: effect of TGF-α and TGF-Βon epidermal structure in vitro

✍ Scribed by S. Kondo; Y. Hozumi; H. Maejima; K. Aso

Publisher: Springer-Verlag
Year: 1992
Tongue: English
Weight: 990 KB
Volume: 284
Category: Article
ISSN: 0340-3696
DOI: 10.1007/bf00372708

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✦ Synopsis

Recently, various growth factors have been reported to be related to epidermal proliferation and differentiation. One of them is TGF-a, which has been found to be produced in the intact viable epidermal layer [3] as well as to exert an effect on it via EGF receptors on epidermal cells [12,13], as TGF-~ interacts with the same receptor as EGF [5]. Over-expression of TGF-~ in psoriatic epidermis [6,15], and, in particular the association of psoriatic epidermal hyperplasia with increased expression of TGF-~ (a kcratinocyte mitogen) rather than with Correspondence to: S. Kondo deficient expression of TGF-[3 (a growth inhibitor) [6] have been reported.

We attempted to observe the effects of TGF-~ and TGF-]3 on normal skin and uninvolved and involved psoriatic skin specimens maintained in vitro in organ culture.

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