✦ LIBER ✦

Org 3770 (mirtazapine) versus trazodone: A placebo controlled trial in depressed elderly patients

✍ Scribed by James A. Halikas

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 741 KB
Volume: 10
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470100807

No coin nor oath required. For personal study only.

✦ Synopsis

Results are reported from a randomized, double-blind, trazodone-and placebo-controlled, 6 weeks' eficacy and safety study of a new antidepressant Org 3770 (RemeronB), in 150 outpatients over 55 years of age, with a DSM 111 diagnosis of moderate to severe major depressive disorder. On the 21-item HAMD, the differences between Org 3770 and placebo were statistically significant at weeks 2, 3, 4 and 6 in both Observed Case and Last Observation Carried Forward analyses. Statistically significant differences between both active compounds and placebo were registered at weeks 2 and 3 on the MADRS. The treatments with both Org 3770 and trazodone were associated with a significantly higher frequency of somnolence and dry mouth as compared to placebo, whereas treatment with trazodone also resulted in significantly higher frequencies of dizziness and blurred vision as compared to placebo.

📜 SIMILAR VOLUMES

A randomised, double-blind, placebo-cont

A randomised, double-blind, placebo-controlled, 5-weeks' study of org 3770 (mirtazapine) in major depression

✍ M. C. Khan 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 433 KB

Fifty-four hospitalised and outpatients with a DSM 111 diagnosis of major depressive disorder and 21-item HPRSD score of 2 18, were randomised to 5 weeks' of treatment with either Org 3770 (n=27; 20-60mg/day) or placebo (n = 27). The treatment with Org 3770 resulted in statistically significant and

Org 3770 versus amitriptyline: A 6-week

Org 3770 versus amitriptyline: A 6-week randomized double-blind multicentre trial in hospitalized depressed patients

✍ Milana Zivkov; Geoff D. De Jongh 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 608 KB

Following a placebo washout period of 3-7 days, 251 hospitalized patients with a major depressive episode (DSM I11 and RDC criteria) were treated with either Org 3770 (20-60 mg/day) or amitnptyline (75-225 mg/day) for six consecutive weeks in this randomized, double-blind, multicentre study. Forty-o

Placebo-controlled treatment trial of de

Placebo-controlled treatment trial of depression in elderly physically ill patients

✍ Mavis Evans; Margaret Hammond; Kenneth Wilson; Michael Lye; John Copeland 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 2 views

## Objectives: To determine the response of physically ill elderly depressed patients to treatment. ## Design: Acute geriatric medical inpatients with depression, randomly assigned to an 8-week double-blind placebo-controlled trial of fluoxetine. ## Main outcome measure: Response rate as define

Efficacy of Org 3770 (mirtazapine) vs am

Efficacy of Org 3770 (mirtazapine) vs amitriptyline in patients with major depressive disorder: A meta-analysis

✍ MD. MSc Milana Zivkov; Kit C. B. Roes; Adri G. Pols 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 713 KB

## Oss, The NetherlandF Results are presented from a meta-analysis performed on short-term efficacy data from five randomized, doubleblind, amitriptyline-controlled studies of Org 3770. All participating patients (n = 814) had a DSM I11 diagnosis of moderate or severe Major Depressive Episode, and

Melatonin decreases delirium in elderly

Melatonin decreases delirium in elderly patients: A randomized, placebo-controlled trial

✍ Tareef Al-Aama; Christopher Brymer; Iris Gutmanis; Sarah M. Woolmore-Goodwin; Ja 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 123 KB 👁 1 views

## Abstract ## Background Disturbance in the metabolism of tryptophan and tryptophan‐derived compounds (e.g., melatonin) may have a role in the pathogenesis of delirium. ## Objective To evaluate the efficacy of low dose exogenous melatonin in decreasing delirium. ## Design A randomized, double

Laughter yoga versus group exercise prog

Laughter yoga versus group exercise program in elderly depressed women: a randomized controlled trial

✍ Mahvash Shahidi; Ali Mojtahed; Amirhossein Modabbernia; Mohammad Mojtahed; Abdol 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB

## Abstract ## Background Laughter Yoga founded by M. Kataria is a combination of unconditioned laughter and yogic breathing. Its effect on mental and physical aspects of healthy individuals was shown to be beneficial. ## Objective The objective of this study was to compare the effectiveness of