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Efficacy of Org 3770 (mirtazapine) vs amitriptyline in patients with major depressive disorder: A meta-analysis

✍ Scribed by MD. MSc Milana Zivkov; Kit C. B. Roes; Adri G. Pols

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 713 KB
Volume: 10
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470100808

No coin nor oath required. For personal study only.

✦ Synopsis

Oss, The NetherlandF

Results are presented from a meta-analysis performed on short-term efficacy data from five randomized, doubleblind, amitriptyline-controlled studies of Org 3770. All participating patients (n = 814) had a DSM I11 diagnosis of moderate or severe Major Depressive Episode, and the majority of them was hospitalized. Efficacy of treatments was compared on an Intent-to-Treat basis; 732 patients were available for this type of analysis. Primary efficacy variables were changes from baseline in group mean 17-item HAMD scores and percentages of responders. The results of the meta-analysis are in agreement with those from individual studies, consistently showing that there are no statistically nor clinically relevant differences in efficacy of Org 3770 and amitriptyline throughout the study period and at endpoint.

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