𝔖 Bobbio Scriptorium
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Ordered forms of 5′-8-aminoguanylic acid

✍ Scribed by Masao Hattori; Joe Frazier; H. Todd Miles

Book ID
102763775
Publisher
Wiley (John Wiley & Sons)
Year
1975
Tongue
English
Weight
624 KB
Volume
14
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

5′‐8NH~2~GMP forms an ordered structure in moderately acid (p__D__ 4.7) solution. We propose for this ordered form a novel hemiprotonated G·G structure with a twofold rotation axis and three hydrogen bonds between each pair of guanine residues. Gel formation does not occur with this nucleotide in either neutral or acid solution. In neutral solution 5′‐8NH~2~GMP also forms a regular, ordered structure, quite different from the acid form and similar to that formed by 5′‐GMP under the same neutral conditions. We suggest that this ordered structure consists of a regularly stacked array of planar tetramers, similar to that proposed for 3′‐GMP at pH 5.^2^

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