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Oral Gossypol in the Treatment of Patients with Refractory Metastatic Breast Cancer: A Phase I/II Clinical Trial

✍ Scribed by Catherine Van Poznak; Andrew D. Seidman; Marcus M. Reidenberg; Mark M. Moasser; Nancy Sklarin; Kimberly Van Zee; Patrick Borgen; Marc Gollub; Doreen Bacotti; T-J Yao; Renny Bloch; Monica Ligueros; Martin Sonenberg; Larry Norton; Clifford Hudis

Book ID
110294388
Publisher
Springer US
Year
2001
Tongue
English
Weight
180 KB
Volume
66
Category
Article
ISSN
0167-6806

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## Abstract ## BACKGROUND The similarity between the mechanism of action between docetaxel and estramustine generated the hypothesis of synergistic antimicrotubule effects and cytotoxicity when the two agents are combined. In addition, it has been demonstrated that estramustine binds P‐glycoprotei