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Oral Fluoropyrimidines in the Treatment of Colorectal Cancer

โœ Scribed by D. Bissett; F. Ahmed; H. McLeod; J. Cassidy

Book ID
111720089
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
106 KB
Volume
12
Category
Article
ISSN
1433-2981

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โœ Francesco Di Costanzo; Andrea Sdrobolini; Silvia Gasperoni ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 200 KB

Capecitabine (Xeloda) ยฎ was developed as a tumour-selective fluoropyrimidine carbamate to achieve higher intratumoural 5-FU level and lower toxicity than 5-FU. Capecitabine passes unchanged through the gastrointestinal tract and is metabolised in the liver to 5%-deoxy-5-fluorocytidine (5%-DFCR). Her