Rats received haloperidol (1.3-1.5 mg/kg/day) via their drinking water for 21 weeks. At the end of this period the density of D2 dopamine receptors and their affinity for [3H]-spiperone were measured in the striatum and medial prefrontal cortex. The chronic haloperidol treatment increased the densit
โฆ LIBER โฆ
Oral administration of the antiobesity drugs, sibutramine and rimonabant, increases acetylcholine efflux selectively in the medial prefrontal cortex of the rat
โ Scribed by Davis, R J; Nomikos, G G
- Book ID
- 110060385
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 153 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1359-4184
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Previous research has indicated that atypical antipsychotic drugs like clozapine preferentially increase dopamine (DA) release from the mesocortical, relative to the nigrostriatal, system. While these drugs generally have weak affinity for the D2 receptor subtype, they are potent antagonists of the