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Optimum in vitro expansion of human antigen-specific CD8+ T cells for adoptive transfer therapy

✍ Scribed by M. Montes; N. Rufer; V. Appay; S. Reynard; M. J. Pittet; D. E. Speiser; P. Guillaume; J.-C. Cerottini; P. Romero; S. Leyvraz

Book ID: 108699221
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 516 KB
Volume: 142
Category: Article
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2005.02914.x

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## Abstract The requirements for the conversion of CD8^+^ memory T cells into effector class I major histocompatibility complex (MHC) K^d^−restricted cytotoxic T (T~c~) cells __in vitro__ have been studied. Purified CD8^+^splenocytes from influenza A/WSN‐primed BALB/c (H‐2^d^) mice stimulated with