## Abstract Spontaneous tumors frequently express antigens that can be recognized by the immune system but nevertheless manage to evade immune surveillance. To better understand the mechanism of evasion, we followed CD8 and CD4 T cells reacting against a subcutaneously growing tumor, modified to ex
Tumor progression inhibits the induction of multifunctionality in adoptively transferred tumor-specific CD8+ T cells
β Scribed by Naoko Imai; Hiroaki Ikeda; Isao Tawara; Hiroshi Shiku
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 370 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## BACKGROUND. Most strategies in cancer immunotherapy are aimed at the induction of a strong cellular immune response against the tumor. Particularly, CD8 + T lymphocytes have been proven in multiple animal models to be critical for the eradication of solid tumors. METHODS. We used a population o
MOPC315 plasmacytoma [9], was employed. Upon processing, the U3'' L chain yields a CDR3-fragment comprising residues 91-101. This Id-peptide is presented on the I-Ed class 11 molecule. Amino acids Phe94, Arg9', of the
We established gastric cancer-specific CD8 1 T-cell (T CD8 1) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T CD8 1 derived from
Murine epidermis contains 2 distinct cell populations which contribute to the skin immune system, Langerhans cells (LC), and dendritic epidermal T cells (DETC). LCs are important in the induction of immunity against a wide range of antigens; however, the function of DETC is unclear. To investigate t