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Optimizing sensitivity and resolution in time-shared NMR experiments

✍ Scribed by Miriam Pérez-Trujillo; Pau Nolis; Wolfgang Bermel; Teodor Parella

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
321 KB
Volume
45
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

An improved approach to optimize the overall sensitivity and the resolution requirements in the indirect dimension of ^13^C/^15^N time‐shared (TS) NMR experiments is presented. A different data sampling acquisition procedure is applied for ^13^C and ^15^N in the indirect dimension, and a proper data recombination before conventional data processing allows a customized adjustment of spectral widths, number of scans and number of increments individually for ^13^C and ^15^N. The major benefit is an important improvement on the detection limits of the TS experiment that overcomes the lower sensitivity of ^15^N over ^13^C at natural abundance. We evaluate such enhancements from 2D TS‐HMBC experiments recorded on a nitrogen‐containing synthetic azole derivative of pharmaceutical interest. Copyright © 2007 John Wiley & Sons, Ltd.

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