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Optimizing amino acid composition of CHO cell culture media for a fusion protein production

✍ Scribed by Zizhuo Xing; Brian Kenty; Inna Koyrakh; Michael Borys; Shih-Hsie Pan; Zheng Jian Li

Book ID
108254841
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
546 KB
Volume
46
Category
Article
ISSN
1873-3298

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## Abstract Optimization of fed‐batch feeding parameters was explored for a system with multiple mechanisms of product inactivation. In particular, two separate mechanisms of inactivation were identified for the recombinant tissue‐type activator (r‐tPA) protein. Dynamic inactivation models were wri