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Optimization of the Tet-On system for regulated gene expression through viral evolution

โœ Scribed by Zhou, X; Vink, M; Klaver, B; Berkhout, B; Das, A T

Book ID
110039832
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
344 KB
Volume
13
Category
Article
ISSN
0969-7128

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Improved single-chain transactivators of
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## Background The Tet-Off (tTA) and Tet-On (rtTA) regulatory systems are widely applied to control gene expression in eukaryotes. Both systems are based on the Tet repressor (TetR) from transposon Tn__10__, a dimeric DNA-binding protein that binds to specific operator sequences (__tetO__). To allow

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The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector
โœ Hiroyuki Mizuguchi; Takao Hayakawa ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 117 KB

## Background: Control of transgene expression in mammalian cells is desirable for gene therapy and the study of gene function in basic research. this study evaluates the functionality of single adenovirus (ad) vectors containing a tetracycline-controllable expression system (tet-off or tet-on syst