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Optimization of tetrachlorosalicylanilide and ultraviolet A doses a sensitization and challenge for contact photosensitivity in the mouse

✍ Scribed by W. R. Brown; R. D. Furukawa; G. M. Shivji; C. A. Ramsay

Publisher: Springer-Verlag
Year: 1989
Tongue: English
Weight: 335 KB
Volume: 281
Category: Article
ISSN: 0340-3696
DOI: 10.1007/bf00412981

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✦ Synopsis

We studied contact photosensitivity (CPS) to tetrachlorosalicylanilide (TCSA) in BALB/cJ mice with various doses of TCSA and UVA at sensitization and challenge. From these studies we recommend the following protocol: sensitization on days 0 and 1 with 50/d of 1% TCSA followed by 3 J[cm 2 of UVA, and challenge on day 7 with 10/~1 of 3% TCSA followed by 6 J]cm 2 of UVA. This gave an ear swelling response of 27.4 _+ 0.6 • 10-3 (mean + standard error). We also demonstrated that there is reciprocity between volume and concentration of TCSA at sensitization but not between TCSA and UVA doses at sensitization.

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