✦ LIBER ✦

Optimization of supercritical fluid extraction of saikosaponins from Bupleurum falcatum with orthogonal array design

✍ Scribed by Yinshi Sun; Li Wei; Jianhua Wang; Jianjie Bi; Zhengbo Liu; Ying Wang; Zude Guo

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 191 KB
Volume: 33
Category: Article
ISSN: 1615-9306
DOI: 10.1002/jssc.200900529

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Supercritical fluid extraction (SFE) was used to extract saikosaponins a, c and d from the root of Bupleurum falcatum. An orthogonal array design L~9~(3)^4^ was employed as a chemometric method for the optimization of the SFE conditions. The effects of four factors including pressure (30–40 MPa), temperature (40–50°C), ethanol concentration (60–100%) and time (2.5–3.5 h) on the yields of saikosaponins were investigated by a preparative SFE system in the SFE mode. Under the optimized conditions, namely 35 MPa of pressure, 45°C of temperature, 80% of ethanol concentration and 3.0 h of time, the yields of saikosaponin c, saikosaponin a, saikosaponin d, total saikosaponins and SFE extract were 0.16, 0.12, 0.96, 1.24 and 16.48 mg/g, respectively. Determinations of the saikosaponins were performed by HPLC.

📜 SIMILAR VOLUMES

Orthogonal array design for the optimiza

Orthogonal array design for the optimization of supercritical fluid extraction of tanshinones from Danshen

✍ Longhu Wang; Yanting Song; Yiyu Cheng; Xuesong Liu 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 751 KB

## Abstract Different from the west medicine, the therapeutic effect of the traditional Chinese medicine is usually based on multifarious essential components or the combination of them instead of only one component. In this paper, a novel supercritical fluid extraction (SFE) method has been develo

Orthogonal array design for the optimiza

Orthogonal array design for the optimization of supercritical fluid extraction of baicalin from roots of Scutellaria baicalensis Georgi

✍ Yiling Chang; Ben Liu; Bo Shen 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 365 KB

## Abstract Supercritical fluid was used to extract baicalin from the roots of __Scutellaria baicalensis__ Georgi. An orthogonal array design (OAD), OA~9~(3^4^), was employed as a chemometric method for the optimization of the supercritical fluid extraction of baicalin from the herbal medicine. Fou

Optimization of Supercritical Fluid Extr

Optimization of Supercritical Fluid Extraction by Carbon Dioxide with Organic Modifiers of Polycyclic Aromatic Hydrocarbons from Urban Particulate Matter

✍ Vito Librando; Gaetano Tomaselli; Giuseppe Tringali 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 57 KB 👁 2 views

## Abstract The main advantages of using supercritical fluids for the extractions of organic pollutants from environmental matrix is that they are inexpensive, contaminant free, and less costly to dispose safely than organic solvents. In this work, a series of extraction experiments were carried ou