✦ LIBER ✦

Optimization of spiroimidazolidinone derivatives synthesis on solid phase using SynPhase™ Lanterns

✍ Scribed by Philippe Bedos; Lidia Feliu; Jean Martinez; Muriel Amblard

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 102 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01083-9

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✦ Synopsis

We report the synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives from N-benzyl-4-piperidone and N-protected amino acid amides on solid support. We have translated the chemistry from solution to solid phase using a backbone amide linker (BAL) mimic. Using a parallel combinatorial approach, we performed the optimization of the synthesis on SynPhase™ Lanterns.

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