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Optimization of Magnetization Transfer Experiments to Measure First-Order Rate Constants and Spin-Lattice Relaxation Times

✍ Scribed by Hormuzd Katki; George H. Weiss; James E. Kiefer; Haim Taitelbaum; Richard G. S. Spencer

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
559 KB
Volume
9
Category
Article
ISSN
0952-3480

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✦ Synopsis

A recent analysis of the optimization of magnetization transfer experiments to estimate first-order rate constants is extended to the design of experiments for measuring these constants and T , when both parameters are initially unknown. When the number of measurement times is fixed, an optimal design will consist of a set of measurement times which ensures that the precision of the estimates of the combination of k and T, is as small as possible in a worst-case scenario. Simple expressions are given for the parameters that characterize the optimal design.

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