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Optimization of Glycosylation Reactions in a Microreactor

✍ Scribed by Karolin Geyer; Peter H. Seeberger

Publisher
John Wiley and Sons
Year
2007
Tongue
German
Weight
368 KB
Volume
90
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Glycosylations are notoriously difficult reactions that require extensive optimization regarding the type of anomeric leaving group, solvent, reaction temperature, and reaction time. Described is the use of a silicon‐based microreactor to screen reaction conditions and to scale‐up synthetic procedures. For the first time, glycosyl phosphates were employed in a microreactor. The optimized reaction conditions were successfully transferred to a batch process.

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