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Microreactor-Based Reaction Optimization in Organic Chemistry — Glycosylation as a Challenge.

✍ Scribed by Daniel M. Ratner; Edward R. Murphy; Manish Jhunjhunwala; Daniel A. Snyder; Klavs F. Jensen; Peter H. Seeberger


Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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Optimization of Glycosylation Reactions
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## Abstract Glycosylations are notoriously difficult reactions that require extensive optimization regarding the type of anomeric leaving group, solvent, reaction temperature, and reaction time. Described is the use of a silicon‐based microreactor to screen reaction conditions and to scale‐up synth