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Optimization of fluorescence detection for the determination of labetalol in plasma by high-performance liquid chromatography

✍ Scribed by V. Ostrovská; X. Svobodová; A. Pechová; S. Kusala; M. Svoboda

Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
279 KB
Volume
446
Category
Article
ISSN
1873-3778

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✦ Synopsis

A sensitive reversed-phase high-performance liquid chromatographic method for the determination of labetalol has been developed. A mobile phase consisting of citrate buffer (pH 6.5) acetonitrile and 2-propanol and an RP-8 column were used. The sensitivity of the fluorescence detection was enhanced to 1 ng/ml of labetalol in plasma by optimizing the emitted light. General guidelines for optimization of fluorescence detection are discussed.

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