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Optimization of Batch and Fed-Batch Bioreactors using Simulated Annealing

โœ Scribed by Ioannis K. Kookos


Book ID
109386907
Publisher
American Institute of Chemical Engineers
Year
2004
Tongue
English
Weight
65 KB
Volume
20
Category
Article
ISSN
8756-7938

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Dynamic optimization of hybridoma growth
โœ Sanjeev Dhir; K. John Morrow Jr.; R. Russell Rhinehart; Theodore Wiesner ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 180 KB ๐Ÿ‘ 2 views

This study addressed the problem of maximizing cell mass and monoclonal antibody production from a fed-batch hybridoma cell culture. We hypothesized that inaccuracies in the process model limited the mathematical optimization. On the basis of shaker flask data, we established a simple phenomenologic