Optimization in Drug Discovery || In Situ Single-Pass Perfused Rat Intestinal Model for Absorption and Metabolism
โ Scribed by Yan, Zhengyin; Caldwell, Gary W.
- Book ID
- 120244198
- Publisher
- Humana Press
- Year
- 2004
- Weight
- 282 KB
- Category
- Article
- ISBN
- 1592598005
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Modulation of intestinal drug absorption barriers can have a profound impact on the bioavailability of orally administered compounds. With its commonality of use as an absorption model, it is valuable to assess the role of such barriers in the rat intestinal mucosa. In the present study, atenolol an
Methods of analyzing drug absorption data from rat intestinal-perfusion experiments are discussed in terms of mass-transfer resistances, or reciprocal permeabilities, and mass balances. Typically, a two-resistance model is used to determine the dimensionless effective permeability (P\*eff) by measur