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Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma

โœ Scribed by J Ayrton; G.J Dear; W.J Leavens; D.N Mallett; R.S Plumb

Book ID
108341550
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
139 KB
Volume
828
Category
Article
ISSN
1873-3778

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Ultra-high flow rate capillary liquid chromatography with mass spectrometric detection for the direct analysis of pharmaceuticals in plasma at sub-nanogram per millilitre concentrations
โœ J. Ayrton; R. A. Clare; G. J. Dear; D. N. Mallett; R. S. Plumb ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 105 KB ๐Ÿ‘ 3 views

Ultra-high flow rate liquid chromatography on large particle size stationary phases coupled with mass spectrometric detection (particularly tandem mass spectrometry, MS/MS) is gaining increasing usage for the direct determination of pharmaceuticals in biological fluids. The lack of sample preparatio