Ultra-high flow rate liquid chromatography on large particle size stationary phases coupled with mass spectrometric detection (particularly tandem mass spectrometry, MS/MS) is gaining increasing usage for the direct determination of pharmaceuticals in biological fluids. The lack of sample preparatio
โฆ LIBER โฆ
Assessment of the in-vivo stereochemical integrity of aprepitant based on the analysis of human plasma samples via high-performance liquid chromatography with mass spectrometric detection
โ Scribed by W. F. Kline; E. J. Woolf; B. K. Matuszewski
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 112 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0269-3879
- DOI
- 10.1002/bmc.472
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A sensitive, specific, accurate and reproducible analytical method was developed and validated for the quantitation of the anticancer agent paclitaxel in human plasma. This procedure is based on high performance liquid chromatography/ion spray -tandem mass spectrometry. This methodology is highly sp