Metaiodobenzylguanidine (MIBG) has been used for the detection and treatment of neuroectodermal tumors, including neuroblastoma. We report our experience with I3'l- MIBG used diagnostically in neuroblastoma patients with relapse. Thirtyeight studies were performed in 26 patients. There were 24 child
Optimal use of the 131-I-metaiodobenzylguanidine and cisplatin combination in advanced neuroblastoma
β Scribed by Renato Mastrangelo; Assunta Tornesello; Anna Lasorella; Antonio Iavarone; Stefano Mastrangelo; Riccardo Riccardi; Luca Diociaiuti; Vittoria Rufini; Andrea Pession; Luigi Troncone
- Book ID
- 110229075
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 38 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0167-594X
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Background. Standard chemo-radiotherapy methods for the treatment of children with advanced neuroblastoma (NBL) including bone marrow transplant approaches have been disappointing. These poor results can be ascribed to the evolution of residual drug-resistant cell populations. Curative attempts shou
Effects of high activities of I 131 meta-iodobenzylguanidine (mIBG) were evaluated in nine children with advanced neuroblastoma. All patients had been previously heavily treated and had either primarily refractory disease or resistant relapse. Twenty-two doses of mIBG labeled with 1.3 to 4 GBq (35-1