✦ LIBER ✦

I-131 metaiodobenzylguanidine: Diagnostic use in neuroblastoma patients in relapse

✍ Scribed by Heyman, Sydney ;Evans, Audrey E. ;D'Angio, Giulio J.

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 420 KB
Volume: 16
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950160509

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✦ Synopsis

Metaiodobenzylguanidine (MIBG) has been used for the detection and treatment of neuroectodermal tumors, including neuroblastoma. We report our experience with I3'l- MIBG used diagnostically in neuroblastoma patients with relapse. Thirtyeight studies were performed in 26 patients. There were 24 children (range 3 months-I4 years) and two adults. While the study was found to be both sensitive and specific for the presence of dis-ease, there are instances of discordance. Falsenegative studies were found with a markedly anaplastic tumor and with two mature ganglioneuromas. A bone lesion was negative with 1311-MIBC, but positive on bone scan. A biopsy confirmed the presence of neuroblastoma. Caution should be exercised when scanning pretreated patients, and perhaps with newly diagnosed patients as well.

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