𝔖 Bobbio Scriptorium
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Optimal sampling times for minimum variance of clearance determination.

✍ Scribed by M Dossing; A Volund; HE Poulsen


Book ID
117943077
Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
831 KB
Volume
15
Category
Article
ISSN
0306-5251

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## It is shown how Crame Β΄r-Rao theory may be used to determine Here we use the theory of Crame Β΄r-Rao lower bounds (5the optimal sampling pattern for measuring the NMR spin-spin 8) to determine the optimum choice of sampling times for relaxation time, T 2 . The results may also be applied to the

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Measurements of relaxation times in proteins are a valu-simple approach is to measure the efficiency of a sampling pattern applied to several different values of T by the able source of information about molecular motions in biological macromolecules such as proteins (1-3). Relaxation reliability ac