Optimal restricted two-stage designs
✍ Scribed by L.Douglas Case; Timothy M. Morgan; C.E. Davis
- Book ID
- 119143458
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 710 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0197-2456
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## Abstract Genome‐wide association (GWA) studies require genotyping hundreds of thousands of markers on thousands of subjects, and are expensive at current genotyping costs. To conserve resources, many GWA studies are adopting a staged design in which a proportion of the available samples are geno
## Abstract The much‐anticipated fixed‐array, genome‐wide SNP genotyping technologies make large‐scale genome‐wide association scans now possible for large numbers of subjects. In this paper we reconsider the problem (Satagopan and Elston [2003] Genet Epidemiol 25:149–157) of optimizing a two‐stage