In the conduct of a phase II cancer clinical trial, patients usually enter in two stages. If the response rate from the first stage is low, then the study terminates. Within various two-stage designs, Simon proposed the optimal and minimax criteria. In the co-operative group setting, practical consi
β¦ LIBER β¦
Optimal Phase II Trials
β Scribed by Gary B. Weiss and James A. Hokanson
- Book ID
- 125760327
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 376 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0006-341X
- DOI
- 10.2307/2531604
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Optimal flexible designs in phase II cli
β
T. Timothy Chen; Tie-Hua Ng
π
Article
π
1998
π
John Wiley and Sons
π
English
β 107 KB
π 2 views
Bayesian Optimal Design for Phase II Scr
β
Meichun Ding; Gary L. Rosner; Peter MΓΌller
π
Article
π
2007
π
John Wiley and Sons
π
English
β 985 KB
Optimal two-stage designs for phase II c
β
Richard Simon
π
Article
π
1989
π
Elsevier Science
π
English
β 594 KB
Optimal three-stage designs for phase II
β
T. Timothy Chen
π
Article
π
1997
π
John Wiley and Sons
π
English
β 136 KB
π 2 views
The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at
Optimizing randomized phase II trials as
β
Andrew Stone; Catherine Wheeler; Kevin Carroll; Alan Barge
π
Article
π
2007
π
Elsevier Science
π
English
β 129 KB
Optimal sample sizes for phase II clinic
β
Nigel Stallard
π
Article
π
2011
π
John Wiley and Sons
π
English
β 499 KB